Ameliorative Effect of Vitamin E on Cypermethrin Induced Hepatotoxicity and Oxidative Stress in Male Wistar Rats

The present study was carried out to investigate the ameliorative effect of vitamin E on Cypermethrin induced hepatotoxicity and oxidative stress. For this purpose, a total of 24 rats were randomly divided into four equal groups: group I used as control and groups II, III and IV were orally treated with Cypermethrin (25 mg/kg body weight), Vitamin E (100 mg/kg body weight) and Cypermethrin (25 mg/kg body weight) plus Vitamin E (100mg/kg body weight), respectively for 45 days. Results showed that on administration of Cypermethrin the mean values of superoxide dismutase (SOD) decreased significantly. Similarly the mean values of reduced glutathione (GSH) and catalase were significantly decreased, while there was significant increase in the mean value of lipid peroxidation (LPO) in liver homogenate . Enzymatic activities of aspartate aminotransferase (AST), alanine (ALT) and alkaline phosphatase (ALP) in plasma were significantly increased due to Cypermethrin administration. Further, light microscope investigation revealed that Cypermethrin exposure induced histopathological alterations in the liver tissue. On the other hand; treatment with Vitamin E alleviated the harmful effect of Cypermethrin in the group (Group IV). Thus, present study revealed that the presence of Vitamin E could diminish the hepatotoxicity and oxidative stress in male wistar rats.